Description
SereneQ Cagrilintide
Cagrilintide is a long-acting acylated amylin analogue developed by Novo Nordisk. Amylin is a 37-amino acid peptide co-secreted with insulin from pancreatic beta cells. It slows gastric emptying, suppresses glucagon secretion and acts centrally to reduce appetite through amylin receptors in the area postrema. The natural amylin molecule has poor pharmacokinetic properties for therapeutic use; cagrilintide is engineered to have a half-life suitable for once-weekly injection.
What the research covers
The most significant research programme is CagriSema — the combination of cagrilintide with semaglutide (a GLP-1 receptor agonist) being developed as a dual amylin/GLP-1 approach. Phase 2 data published in The Lancet showed approximately 15% weight loss with CagriSema at 16 weeks, exceeding semaglutide alone. Phase 3 REDEFINE trials are ongoing. The rationale for combination is mechanistic diversity: GLP-1 agonists and amylin analogues act through different receptors and complementary pathways, so their combination produces additive rather than merely overlapping effects on appetite and body weight.
Where the evidence sits
Phase 3 trials ongoing as of 2026. Does not hold a medicines licence as a standalone compound or as CagriSema. Supplied strictly as a laboratory research chemical.
The pen format
This is where SereneQ does things differently. Instead of lyophilised vials that need reconstituting and drawing up separately, the compound arrives pre-loaded in solution in a graduated injection pen with a dial and a dose window.
- Cagrilintide (amylin analogue) in pre-loaded solution
- Graduated dial with dose window
- 300 units total per pen
- 4 × sealed pen tips, 32G 0.23 × 4mm
- Store refrigerated at 2–8°C. Do not freeze.
- Batch number, expiry and serial printed directly on the pen barrel
Handling and storage
- Store refrigerated at 2–8°C. Do not freeze.
- Keep in the outer carton, away from direct light.
- Short periods at room temperature during transit are expected and normal.
- Use a fresh sealed tip for each dispense. Dispose of tips in a sharps container.
- Expiry 12/2027 on sealed, correctly stored stock.
- Keep out of reach of children and animals.
What is in the box
- 1 × SereneQ pre-filled injection pen
- 4 × sealed pen tips, 32G 0.23 × 4mm
- Serialised, QR-coded retail carton
Supplied strictly as a laboratory research chemical. Not licensed as a medicine in the UK or anywhere else. Not for human or veterinary use. The research cited covers animal and in vitro work unless otherwise stated.





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