Description
SereneQ HGH Fragment 176-191
HGH Fragment 176-191 (AOD-9604) is a modified form of amino acids 176 through 191 from the C-terminus of human growth hormone. The full somatropin molecule has separate domains responsible for different aspects of its activity — the N-terminal region is primarily responsible for anabolic and growth-promoting effects via IGF-1 stimulation, while the C-terminal region around residues 176-191 is the area believed to mediate the lipolytic (fat-breaking) activity. The fragment was developed specifically to isolate that lipolytic activity.
What the research covers
Animal studies with AOD-9604 showed reductions in body fat, particularly visceral and subcutaneous, without the IGF-1 elevation, glucose dysregulation or tissue growth effects seen with full somatropin. The mechanism appears to involve beta-3 adrenergic receptor stimulation and direct effects on fat cell metabolism. It entered human clinical trials for obesity but did not demonstrate sufficient efficacy to proceed to Phase 3. The research interest remains in the principle of isolating the lipolytic activity of GH from its anabolic effects — an approach that has informed subsequent fat-loss peptide research.
Where the evidence sits
Phase 2 clinical data exists but efficacy was insufficient for approval. Not licensed as a medicine. Supplied strictly as a laboratory research chemical.
The pen format
This is where SereneQ does things differently. Instead of lyophilised vials that need reconstituting and drawing up separately, the compound arrives pre-loaded in solution in a graduated injection pen with a dial and a dose window.
- HGH Fragment 176-191 in pre-loaded solution
- Graduated dial with dose window
- 300 units total per pen
- 4 × sealed pen tips, 32G 0.23 × 4mm
- Batch number, expiry and serial printed directly on the pen barrel
Handling and storage
- Store refrigerated at 2–8°C. Do not freeze.
- Keep in the outer carton, away from direct light.
- Short periods at room temperature during transit are expected and normal.
- Use a fresh sealed tip for each dispense. Dispose of tips in a sharps container.
- Expiry 12/2027 on sealed, correctly stored stock.
- Keep out of reach of children and animals.
What is in the box
- 1 × SereneQ pre-filled injection pen
- 4 × sealed pen tips, 32G 0.23 × 4mm
- Serialised, QR-coded retail carton
Supplied strictly as a laboratory research chemical. Not licensed as a medicine in the UK or anywhere else. Not for human or veterinary use. The research cited covers animal and in vitro work unless otherwise stated.





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