Description
SereneQ 5-Amino-1MQ
5-Amino-1MQ (5-amino-1-methylquinolinium) is a small molecule inhibitor of nicotinamide N-methyltransferase (NNMT) — an enzyme expressed primarily in adipose tissue and liver that methylates nicotinamide, consuming SAM (S-adenosylmethionine) in the process. By inhibiting NNMT, 5-Amino-1MQ preserves the methyl donor pool and raises intracellular NAD+ levels in fat cells, which in turn activates SIRT1 and other NAD+-dependent pathways. The mechanism is different from direct NAD+ precursors — it works upstream by reducing consumption rather than increasing supply.
What the research covers
Animal studies have shown that NNMT inhibition with 5-Amino-1MQ produces reductions in fat mass, particularly white adipose tissue, with some evidence of a shift toward brown adipocyte characteristics — increased mitochondrial content and uncoupling protein expression. Studies have also examined its effects on lipogenesis, lipolysis and adipocyte differentiation. The NAD+/SIRT1 mechanism connects it to the broader longevity pathway literature. It has attracted research interest as an alternative approach to metabolic intervention that does not require receptor agonism or secretagogue activity.
Where the evidence sits
All published data is animal or cell culture. No human clinical trials have been published. Does not hold a medicines licence anywhere. Supplied strictly as a laboratory research chemical.
The pen format
This is where SereneQ does things differently. Instead of lyophilised vials that need reconstituting and drawing up separately, the compound arrives pre-loaded in solution in a graduated injection pen with a dial and a dose window.
- 5-Amino-1MQ in pre-loaded solution
- Graduated dial with dose window
- 300 units total per pen
- 4 × sealed pen tips, 32G 0.23 × 4mm
- Batch number, expiry and serial printed directly on the pen barrel
Handling and storage
- Store refrigerated at 2–8°C. Do not freeze.
- Keep in the outer carton, away from direct light.
- Short periods at room temperature during transit are expected and normal.
- Use a fresh sealed tip for each dispense. Dispose of tips in a sharps container.
- Expiry 12/2027 on sealed, correctly stored stock.
- Keep out of reach of children and animals.
What is in the box
- 1 × SereneQ pre-filled injection pen
- 4 × sealed pen tips, 32G 0.23 × 4mm
- Serialised, QR-coded retail carton
Supplied strictly as a laboratory research chemical. Not licensed as a medicine in the UK or anywhere else. Not for human or veterinary use. The research cited covers animal and in vitro work unless otherwise stated.





Reviews
There are no reviews yet.