Description
SereneQ Melanotan-1
Melanotan-1 (afamelanotide) is a synthetic analogue of alpha-melanocyte stimulating hormone (α-MSH) with selective activity at the melanocortin-1 receptor (MC1R). It was developed at the same University of Arizona programme that produced Melanotan-2, but was taken forward as a pharmaceutical candidate for photoprotection rather than for its sexual function effects, because MC1R selectivity avoids the central nervous system activity at MC3R and MC4R. It received European Medicines Agency approval in 2014 as Scenesse (implant formulation) for erythropoietic protoporphyria — a rare genetic disorder causing extreme photosensitivity.
What the research covers
MC1R stimulation increases melanogenesis — the production of eumelanin (dark pigment) in melanocytes. This produces tanning and provides photoprotection by absorbing and scattering UV radiation. In the protoporphyria indication, this photoprotection allows patients who would otherwise be unable to tolerate sunlight to spend time outdoors. Research outside EPP has examined afamelanotide in polymorphous light eruption (a common photosensitivity condition) and in vitiligo, with some evidence of repigmentation. There is also interest in its interaction with the immune system through MC1R on immune cells.
Where the evidence sits
EMA-approved for EPP (implant form). The pen format here is not pharmaceutical Scenesse. Supplied strictly as a laboratory research chemical.
The pen format
This is where SereneQ does things differently. Instead of lyophilised vials that need reconstituting and drawing up separately, the compound arrives pre-loaded in solution in a graduated injection pen with a dial and a dose window.
- Melanotan-1 (afamelanotide) in pre-loaded solution
- Graduated dial with dose window
- 300 units total per pen
- 4 × sealed pen tips, 32G 0.23 × 4mm
- Store refrigerated at 2–8°C. Protect from light.
- Batch number, expiry and serial printed directly on the pen barrel
Handling and storage
- Store refrigerated at 2–8°C. Do not freeze.
- Keep in the outer carton, away from direct light.
- Short periods at room temperature during transit are expected and normal.
- Use a fresh sealed tip for each dispense. Dispose of tips in a sharps container.
- Expiry 12/2027 on sealed, correctly stored stock.
- Keep out of reach of children and animals.
What is in the box
- 1 × SereneQ pre-filled injection pen
- 4 × sealed pen tips, 32G 0.23 × 4mm
- Serialised, QR-coded retail carton
Supplied strictly as a laboratory research chemical. Not licensed as a medicine in the UK or anywhere else. Not for human or veterinary use. The research cited covers animal and in vitro work unless otherwise stated.





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