Description
SereneQ SS-31
SS-31 (elamipretide) is a synthetic aromatic-cationic tetrapeptide that selectively concentrates in the inner mitochondrial membrane, where it binds to cardiolipin — a phospholipid that is essentially unique to mitochondria and critical to the organisation and function of the electron transport chain. Cardiolipin content and composition changes with ageing and disease, and these changes are linked to reduced electron transport chain efficiency and increased reactive oxygen species (ROS) production. SS-31 is thought to stabilise the cardiolipin-cytochrome c interaction, which governs the efficiency of electron transfer through Complex I and Complex III.
What the research covers
The majority of published work is in models of ischaemia-reperfusion injury, particularly cardiac. SS-31 has consistently reduced infarct size and improved ventricular function in animal studies of acute MI. Renal ischaemia-reperfusion studies showed similar protective effects. In skeletal muscle, age-related decline in mitochondrial function and exercise capacity has been studied in both animal models and a small Phase 2 human trial in older adults, which showed improvements in muscle ATP synthesis rate measured by phosphorus-31 MRS. The drug is in late-stage clinical development (as MTP-131) for primary mitochondrial myopathy and Barth syndrome.
Where the evidence sits
The most robust human data comes from the muscle ATP synthesis study and the ongoing rare disease programme. It does not hold a general medicines licence. Supplied strictly as a laboratory research chemical.
The pen format
This is where SereneQ does things differently. Instead of lyophilised vials that need reconstituting and drawing up separately, the compound arrives pre-loaded in solution in a graduated injection pen with a dial and a dose window.
- SS-31 (elamipretide) in pre-loaded solution
- Graduated dial with dose window
- 300 units total per pen
- 4 × sealed pen tips, 32G 0.23 × 4mm
- Store refrigerated at 2–8°C. Protect from light.
- Batch number, expiry and serial printed directly on the pen barrel
Handling and storage
- Store refrigerated at 2–8°C. Do not freeze.
- Keep in the outer carton, away from direct light.
- Short periods at room temperature during transit are expected and normal.
- Use a fresh sealed tip for each dispense. Dispose of tips in a sharps container.
- Expiry 12/2027 on sealed, correctly stored stock.
- Keep out of reach of children and animals.
What is in the box
- 1 × SereneQ pre-filled injection pen
- 4 × sealed pen tips, 32G 0.23 × 4mm
- Serialised, QR-coded retail carton
Supplied strictly as a laboratory research chemical. Not licensed as a medicine in the UK or anywhere else. Not for human or veterinary use. The research cited covers animal and in vitro work unless otherwise stated.





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